Out in the world for the very first time, the three innocent bumblers become embroiled in a murder plot and find stardom on a TV reality show. When they learn that financial problems will soon force the only home they've ever known to close, the trio sets out to raise $830,000 in one month.
Left on the doorstep of an orphanage run by nuns, three newborn knuckleheads grow up to be finger-poking, nyuk-nyuking janitors named Larry (Sean Hayes), Curly (Will Sasso) and Moe (Chris Diamantopoulos).